Crossing the Chemistry Chasm
Drug Discovery Collaborations
Advance targets or hits to novel, patentable chemistry using cutting-edge technologies.
Drug Asset Collaborations
Collaborate with Synfini’s research partners on identified targets and hits.
Platform Collaborations
Partner with Synfini’s platform team and help guide the design of our next-generation systems.
Targets and Hits to Drug Candidates
The Synfini Agile Platform advances your targets and hits into optimized, patentable chemistry through multiple entry points. Customize workflows for your target and leverage vast chemistry data to design compounds with the optimal potency, selectivity and ADMET properties for your program.
Empower your bioactivity data with Synfini’s AI-driven modeling solutions. Our Hyperparameter Optimization service allows you to harness the power of SynDesign models through web-based or API-based interfaces.
Synfini’s Parallel Library Synthesis supports the physical exploration of core scaffolds with a need to substitute at different positions and vectors. High throughput synthesis enables rapid SAR exploration around hits and leads.
AI Scaffold Hopping supports the identification of new and / or additional scaffolds with novel patent space, either to initiate a new program or provide alternative approaches in an existing one. Synfini uses it’s AI tools to build target AI models that generate and rank novel virtual scaffold concepts which can then be validated physically.
Leverage Synfini’s AI-powered virtual screening tools to explore vast chemical spaces with unmatched precision. Our predictive models identify promising hit compounds by analyzing potency, selectivity, and ADME properties, enabling faster and smarter decision-making in your discovery pipeline.
AI Virtual Screening searches commercially available compounds to discover novel hits against a target. Synfini curates target data from the literature and partner proprietary information to build predictive AI models which are used to score virtual compounds. Final hits are selected through clustering, target docking and property filtering.
Synfini’s Virtual Hit Synthesis service provides a seamless path from virtual screening to compound realization. Researchers bring their compound designs derived from virtual screens, and Synfini takes care of the rest, developing synthetic routes and creating the final compounds.
Utilize hit series with SAR data and a defined TPP and testing workflow. Synfini will perform multi-objective design of analogs, synthesis, testing and model re-training iteratively. Typical package will include 4 cycles before a Go/No-Go decision point.
The Synfini Scale Up Synthesis Solution supports the scale-up of intermediates, building blocks and lead compounds for advanced testing. Our automated synthesis systems capture detailed synthesis protocols that facilitate complete reproducibility for future scale-up of final compounds as well as for process development.
Multi-step continuous flow chemistry can be developed on Synfini’s AutoSyn system. Synfini performs synthesis planning, route screening and reaction optimization to solve customer challenges in flow scale-up and process development.